Search Results for green-synthesis

Abstract

With the increasing applications of gold nanoparticles in cancer treatment and medical delivery, it has become necessary to study the biological effects of gold nanoparticles. The study aimed to evaluate the biological effects of gold nanoparticles against the mcf-7 & mda-mb-231 cell line. Gold nanoparticles were characterized using several analytical techniques including X-ray Diffraction (XRD), Ultraviolet-Visible Spectroscopy (UV-VIS), Energy Dispersion X-ray (EDX), Atomic Force Microscopy (AFM), and Filed Emission Scanning Electron Microscopy (FE-SEM).. The characterization results confirmed the successful synthesis of high purity quasi-spherical gold nanoparticles with particle sizes ranging from 38 to 59 nm. The cytotoxic effect of the synthesized AuNPs was investigated using the MTT assay on both MCF-7 and MDA-MB-231 cell lines at six different concentrations. The results indicated a concentration-dependent inhibitory effect of gold nanoparticles on both cancer cell lines, with a high cytotoxic activity observed against the MDA-MB-231 cell line. The results of this study indicate the potential use of gold nanoparticles against various types of cancer cell lines, as well as the potential use of gold nanoparticles in treating cancerous diseases with vivo cell.